The pharmaceutical industry uses various methods for particle size analysis including laser diffraction and dynamic light scattering by taking a representative sample from the product and proceeding with air or liquid dispersion. The first method consists of passing a laser beam through the sample. The intensity of the laser light is a clue in determining the particle size. Manufacturers use laser diffraction for various products because it offers fast results, which probably makes it the most popular method. Dynamic light scattering is ideal for macromolecules because it enables a detailed examination concerning the size and weight. This method requires the placement of the particle in a liquid for analyzing the changes in motion. Unlike laser diffraction, this technique is more time-consuming.
Other methods include surface area analysis, optical image analysis and sedimentation analysis. Surface area analysis provides information concerning the porosity of drugs in tablet form, which influences the dissolution rate while optical image analysis helps manufacturers acquire details regarding the shape of the particle. Particle characteristics have the power to influence a drugâs behavior. Bioavailability, which refers to the degree at which the bodyâs circulatory system absorbs the drug, is higher in small particles because dissolution is faster. In terms of dissolution, the surface area of a drug plays a crucial role while uniformity and thickness affect the drugâs performance. To obtain faster processable drugs in tableting systems, particles must have certain shapes that present better flow. This proves the importance of particle size characterization for drugs development.
Considering the importance of particle size process in the pharmaceutics, the goal becomes a major development in terms of instruments that offer the ability to cover a larger variety of particle types and sizes, obtain as much details as possible without too much effort. Professional companies make use of the latest innovations in what concerns the equipment and tools in order to prepare their laboratories for many particle size processes that reveal accurate and specific information. Obviously, specialists with extensive knowledge and years of experience in the field, work shoulder to shoulder, all of them having the purpose to release efficient and safe drugs on the market for customers use because in the end, safety represents the principle on which the pharmaceutical industry is based.
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